Bidirectional connectivity alterations in schizophrenia: a multivariate, machine-learning approach.

ABSTRACT:

Objective

It is well known that altered functional connectivity is a robust neuroimaging marker of schizophrenia. However, there is inconsistency in the direction of alterations, i.e., increased or decreased connectivity. In this study, we aimed to determine the direction of the connectivity alteration associated with schizophrenia using a multivariate, data-driven approach.

Methods

Resting-state functional magnetic resonance imaging data were acquired from 109 individuals with schizophrenia and 120 controls across two openly available datasets. A whole-brain resting-state functional connectivity (rsFC) matrix was computed for each individual. A modified connectome-based predictive model (CPM) with a support vector machine (SVM) was used to classify patients and controls. We

SUBMITTER: Kim M 

PROVIDER: S-EPMC10512460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature