Drug repurposing for Alzheimer's disease from 2012-2022-a 10-year literature review.

ABSTRACT: Background: Alzheimer's disease (AD) is a debilitating neurodegenerative condition with few treatment options available. Drug repurposing studies have sought to identify existing drugs that could be repositioned to treat AD; however, the effectiveness of drug repurposing for AD remains unclear. This review systematically analyzes the progress made in drug repurposing for AD throughout the last decade, summarizing the suggested drug candidates and analyzing changes in the repurposing strategies used over time. We also examine the different types of data that have been leveraged to validate suggested drug repurposing candidates for AD, which to our knowledge has not been previous investigated, although this information may be especially useful in appraising the potential of suggested

SUBMITTER: Grabowska ME 

PROVIDER: S-EPMC10512468 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature