Reducing gut microbiome-driven adipose tissue inflammation alleviates metabolic syndrome.

ABSTRACT:

Background

The gut microbiota contributes to macrophage-mediated inflammation in adipose tissue with consumption of an obesogenic diet, thus driving the development of metabolic syndrome. There is a need to identify and develop interventions that abrogate this condition. The hops-derived prenylated flavonoid xanthohumol (XN) and its semi-synthetic derivative tetrahydroxanthohumol (TXN) attenuate high-fat diet-induced obesity, hepatosteatosis, and metabolic syndrome in C57Bl/6J mice. This coincides with a decrease in pro-inflammatory gene expression in the gut and adipose tissue, together with alterations in the gut microbiota and bile acid composition.

Results

In this study, we integrated and interrogated multi-omics data from different organs with fecal 16S rRNA sequences a

SUBMITTER: Newman NK 

PROVIDER: S-EPMC10512512 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature