Identification of disease-related genes in Plasmodium berghei by network module analysis.

ABSTRACT:

Background

Plasmodium berghei has been used as a preferred model for studying human malaria, but only a limited number of disease-associated genes of P. berghei have been reported to date. Identification of new disease-related genes as many as possible will provide a landscape for better understanding the pathogenesis of P. berghei.

Methods

Network module analysis method was developed and applied to identify disease-related genes in P. berghei genome. Sequence feature identification, gene ontology annotation, and T-cell epitope analysis were performed on these genes to illustrate their functions in the pathogenesis of P. berghei.

Results

33,314 genes were classified into 4,693 clusters. 4,127 genes shared by six malaria parasites were identified and are involved in ma

SUBMITTER: Lin J 

PROVIDER: S-EPMC10512555 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature