Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers.

ABSTRACT:

Background

The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations and challenges in the early diagnosis and targeted treatment of cancers. Accordingly, there is an urgent need to identify novel targets and develop new targeted drugs.

Methods

The study was conducted using combined cis-Mendelian randomization (cis-MR) and colocalization analysis. We analyzed data from 732 plasma proteins to identify potential drug targets associated with eight site-specific cancers. These findings were further validated using the UK Biobank dataset. Then, a protein-protein interaction network was also constructed to examine the interplay betw

SUBMITTER: Ren F 

PROVIDER: S-EPMC10512580 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature