Thrombotic microangiopathies after kidney transplantation in modern era: nosology based on chronology.

ABSTRACT:

Background

Thrombotic microangiopathies (TMAs) are rare but can be severe in kidney transplant. recipients (KTR).

Methods

We analysed the epidemiology of adjudicated TMA in consecutive KTR during the. 2009-2021 period.

Results

TMA was found in 77/1644 (4.7%) KTR. Early TMA (n = 24/77 (31.2%); 1.5% of all KTR) occurred during the first two weeks ((median, IQR) 3 [1-8] days). Triggers included acute antibody-mediated rejection (ABMR, n = 4) and bacterial infections (n = 6). Graft survival (GS) was 100% and recurrence rate (RR) was 8%. Unexpected TMA (n = 31/77 (40.2%); 1.5/1000 patient-years) occurred anytime during follow-up (3.0 (0.5-6.2) years). Triggers included infections (EBV/CMV: n = 10; bacterial: n = 6) and chronic active ABMR (n = 5). GS was 81% and RR was 16%

SUBMITTER: Von Tokarski F 

PROVIDER: S-EPMC10512637 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature