Genomic profile of Chinese patients with endometrial carcinoma.

ABSTRACT:

Backgrounds

Endometrial carcinoma (EC) is one of the most commonly diagnosed gynecologic malignancy in China. However, the genetic profile of Chinese EC patients has not been well established yet.

Methods

In current study, 158 Chinese EC patients were subjected to next-generation sequencing assay (74 took testing of EC-related 20-genes panel, and 84 took the expanded panel). Of the 158 patients, 91 patients were performed germline mutation testing using the expanded panel. Moreover, the public datasets from TCGA and MSKCC were utilized to compare the genomic differences between Chinese and Western EC patients. The proteomic and transcriptomic from CPTAC and TCGA were derived and performed unsupervised clustering to identify molecular subtypes.

Results

Among the 158 pa

SUBMITTER: Li J 

PROVIDER: S-EPMC10512642 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature