Harnessing acoustic speech parameters to decipher amyloid status in individuals with mild cognitive impairment.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative condition characterized by a gradual decline in cognitive functions. Currently, there are no effective treatments for AD, underscoring the importance of identifying individuals in the preclinical stages of mild cognitive impairment (MCI) to enable early interventions. Among the neuropathological events associated with the onset of the disease is the accumulation of amyloid protein in the brain, which correlates with decreased levels of Aβ42 peptide in the cerebrospinal fluid (CSF). Consequently, the development of non-invasive, low-cost, and easy-to-administer proxies for detecting Aβ42 positivity in CSF becomes particularly valuable. A promising approach to achieve this is spontaneous speech analysis, which combined with machin

SUBMITTER: Garcia-Gutierrez F 

PROVIDER: S-EPMC10512723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature