Long-term non-invasive ventilation for COPD patients following an exacerbation with acute hypercapnic respiratory failure: a randomized controlled trial.

ABSTRACT:

Introduction

It remains unclear whether long-term non-invasive ventilation (LT-NIV) for patients with chronic obstructive pulmonary disease (COPD) improves survival and reduces admissions as results from randomized trials are inconsistent. We aim to determine whether LT-NIV initiated after an admission with acute hypercapnic respiratory failure (AHRF) can affect survival and admission rate in COPD patients.

Methods

A randomized controlled open-label trial, allocating patients with COPD to LT-NIV or standard of care immediately after an admission with AHRF treated with acute NIV. LT-NIV was aimed to normalize PaCO₂ using high-pressure NIV.

Results

The study was discontinued before full sample size due to slow recruitment. 28 patients were randomized to LT-NI

SUBMITTER: Hedsund C 

PROVIDER: S-EPMC10512815 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature