An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses.

ABSTRACT: Influenza virus is a prominent cause of respiratory illness in humans. Current influenza vaccines offer strain-specific immunity, while provide limited protection against drifted strains. Broad-spectrum influenza vaccines can induce broad and long-term immunity, and thus are regarded as a future direction for the development of next-generation influenza vaccines. In this study, we have conceptualized a novel mRNA-based multi-antigen influenza vaccine consisting of three conserved antigens of influenza A virus, including the ectodomain of the M2 ion channel (M2e), the long alpha helix of haemagglutinin stalk region (LAH), and nucleoprotein (NP). The vaccine design aims to enhance its potency and promote the development of a future broad-spectrum influenza vaccine. Our mRNA-based vaccine dem

SUBMITTER: Xiong F 

PROVIDER: S-EPMC10512870 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature