Global Odds Model with Proportional Odds and Trend Odds Applied to Gross and Microscopic Brain Infarcts.

ABSTRACT: Medical and epidemiological researchers commonly study ordinal measures of symptoms or pathology. Some of these studies involve two correlated ordinal measures. There is often an interest in including both measures in the modeling. It is common to see analyses that consider one of the measures as a predictor in the model for the other measure as outcome. There are, however, issues with these analyses including biased estimate of the probabilities and a decreased power due to multicollinearity (since they share some predictors). These issues create a necessity to examine both variables as simultaneous outcomes, by assessing the marginal probabilities for each outcome (i.e. using a proportional odds model) and the association between the two outcomes (i.e. using a constant global odds model)

SUBMITTER: Capuano AW 

PROVIDER: S-EPMC10512893 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature