Causal Effects of Gut Microbiota on Age-Related Macular Degeneration: A Mendelian Randomization Study.

ABSTRACT:

Purpose

Recently, the association between gut microbiota and age-related macular degeneration (AMD) through the gut-retina axis has attracted great interest. However, the causal relationship between them has not been elucidated. Using publicly available genome-wide association study summary statistics, we conducted a two-sample Mendelian randomization (MR) analysis to examine the causal relationship between the gut microbiota and the occurrence of AMD.

Methods

The study used a variety of quality control techniques to select instrumental single nucleotide polymorphisms (SNPs) with strong exposure associations. We used a set of SNPs as instrumental variable that were below the genome-wide statistical significance threshold (5 × 10-8). Additionally, a separate group of SNPs bel

SUBMITTER: Mao D 

PROVIDER: S-EPMC10513115 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature