A network pharmacology and molecular docking approach to reveal the mechanism of Chaihu Anxin Capsule in depression.

ABSTRACT:

Introduction

As one of the most frequently diagnosed mental disorders, depression is expected to become the most common disease worldwide by 2030. Previous studies have shown that Chaihu Anxin Capsule has powerful antidepressant effects. However, its mechanisms are not fully understood. The aim of our research is to reveal the mechanisms of Chaihu Anxin Capsule in treating depression.

Methods

Information about the ingredients of the herb was gathered using the TCMSP. Genes associated with antidepressants were gathered from the GeneCards database. An "herbal-ingredient-target" network was constructed and analyzed using Cytoscape software. The PPI network of the antidepressant targets of Chaihu Anxin Capsule was constructed using the STRING database. KEGG pathway and GO enrich

SUBMITTER: Yang L 

PROVIDER: S-EPMC10513492 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature