Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model.

ABSTRACT: Wound dehiscence, oftentimes a result of the poor tensile strength of early healing wounds, is a significant threat to the post-operative patient, potentially causing life-threatening complications. Vanadate, a protein tyrosine phosphatase inhibitor, has been shown to alter the organisation of deposited collagen in healing wounds and significantly improve the tensile strength of incisional wounds in rats. In this study, we sought to explore the effects of locally administered vanadate on tensile strength and collagen organisation in both the early and remodelling phases of excisional wound healing in a murine model. Wild-type mice underwent stented excisional wounding on their dorsal skin and were divided equally into three treatment conditions: vanadate injection, saline injection control

SUBMITTER: Lintel H 

PROVIDER: S-EPMC10513738 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature