Longitudinal Changes in MRI Muscle Morphometry and Composition in People With Inclusion Body Myositis.

ABSTRACT:

Background and objectives

Limited data suggest that quantitative MRI (qMRI) measures have potential to be used as trial outcome measures in sporadic inclusion body myositis (sIBM) and as a noninvasive assessment tool to study sIBM muscle pathologic processes. Our aim was to evaluate changes in muscle structure and composition using a comprehensive multiparameter set of qMRI measures and to assess construct validity and responsiveness of qMRI measures in people with sIBM.

Methods

This was a prospective observational cohort study with assessments at baseline (n = 30) and 1 year (n = 26). qMRI assessments include thigh muscle volume (TMV), inter/intramuscular adipose tissue (IMAT), muscle fat fraction (FF), muscle inflammation (T2 relaxation time), IMAT from T2* relaxation (T2*

SUBMITTER: Laurent D 

PROVIDER: S-EPMC10513877 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature