A single 36-h water-only fast vastly remodels the plasma lipidome.

ABSTRACT:

Background

Prolonged fasting, characterized by restricting caloric intake for 24 h or more, has garnered attention as a nutritional approach to improve lifespan and support healthy aging. Previous research from our group showed that a single bout of 36-h water-only fasting in humans resulted in a distinct metabolomic signature in plasma and increased levels of bioactive metabolites, which improved macrophage function and lifespan in C. elegans.

Objective

This secondary outcome analysis aimed to investigate changes in the plasma lipidome associated with prolonged fasting and explore any potential links with markers of cardiometabolic health and aging.

Method

We conducted a controlled pilot study with 20 male and female participants (mean age, 27.5 ± 4.4 years; m

SUBMITTER: Hong BV 

PROVIDER: S-EPMC10513913 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature