Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase.

ABSTRACT: Insulin action in the human brain modulates eating behaviour, whole-body metabolism and body fat distribution^1,2. In particular, brain insulin action increases whole-body insulin sensitivity, but these studies were mainly performed in lean men^3,4. Here we investigate metabolic and hypothalamic effects of brain insulin action in women with a focus on the impact of menstrual cycle ( ClinicalTrials.gov registration: NCT03929419 ).Eleven women underwent four hyperinsulinemic-euglycemic clamps, two in the follicular phase and two in the luteal phase. Brain insulin action was introduced using nasal insulin spray^5-7 and compared to placebo spray in a fourfold crossover design with change in glucose infusion rate as the primary endpoint. Here we show that during th

SUBMITTER: Hummel J 

PROVIDER: S-EPMC10513929 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature