Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota.

ABSTRACT: Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic responses in several preclinical settings. However, how MR impacts cancer progression in the context of the intact immune system is unknown. Here we report that while inhibiting cancer growth in immunocompromised mice, MR reduces T cell abundance, exacerbates tumour growth and impairs tumour response to immunotherapy in immunocompetent male and female mice. Mechanistically, MR reduces microbial production of hydrogen sulfide, which is critical for immune cell survival/activation. Dietary supplementation of a hydrogen sulfide donor or a precursor, or methionine, stimulates antitumour immunity and suppresses tumour progression. Our findings reveal an un

SUBMITTER: Ji M 

PROVIDER: S-EPMC10513933 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature