Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis.

ABSTRACT: Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral part of sepsis management, fluid resuscitation may also lead to volume overload, which in turn is associated with increased mortality. The optimal fluid strategy in sepsis resuscitation is yet to be defined. Hyaluronan, an endogenous glycosaminoglycan with high affinity to water is an important constituent of the endothelial glycocalyx. We hypothesized that exogenously administered hyaluronan would counteract intravascular volume depletion and contribute to endothelial glycocalyx integrity in a fluid restrictive model of peritonitis. In a prospective, blinded model of porcine peritonitis sepsis, we randomized animals to intervention with hyaluron

SUBMITTER: Tenhunen AB 

PROVIDER: S-EPMC10513979 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature