Impact of elastic substrate on the dynamic heterogeneity of WC256 Walker carcinosarcoma cells.

ABSTRACT: Cellular heterogeneity is a phenomenon in which cell populations are composed of subpopulations that vary in their behavior. Heterogeneity is particularly pronounced in cancer cells and can affect the efficacy of oncological therapies. Previous studies have considered heterogeneity dynamics to be indicative of evolutionary changes within subpopulations; however, these studies do not consider the short-time morphological plasticity of cells. Physical properties of the microenvironment elasticity have also been poorly investigated within the context of cellular heterogeneity, despite its role in determining cellular behavior. This article demonstrates that cellular heterogeneity can be highly dynamic and dependent on the micromechanical properties of the substrate. During observation, migrat

SUBMITTER: Mielnicka A 

PROVIDER: S-EPMC10514059 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature