Ultrasound trapping and navigation of microrobots in the mouse brain vasculature.

ABSTRACT: The intricate and delicate anatomy of the brain poses significant challenges for the treatment of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in hard-to-reach brain regions remains an urgent medical need. Microrobots offer potential solutions; however, their functionality in the brain remains restricted by limited imaging capabilities and complications within blood vessels, such as high blood flows, osmotic pressures, and cellular responses. Here, we introduce ultrasound-activated microrobots for in vivo navigation in brain vasculature. Our microrobots consist of lipid-shelled microbubbles that autonomously aggregate and propel under ultrasound irradiation. We investigate their capacities in vitro within microfluidic-based vasculatures and in vivo with

SUBMITTER: Del Campo Fonseca A 

PROVIDER: S-EPMC10514062 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature