Real-World Response and Outcomes in Patients With NSCLC With EGFR Exon 20 Insertion Mutations.

ABSTRACT:

Introduction

This study describes treatment patterns and outcomes in patients with NSCLC with EGFR exon 20 insertions (EGFRex20ins) in the United States.

Methods

The Flatiron Health electronic health record database was used to select three cohorts among patients diagnosed with NSCLC with EGFRex20ins (January 1, 2011-February 29, 2020): (1) first-line (1L) or patients receiving 1L therapy after documented EGFRex20ins; (2) second or later-line (≥2L) or patients receiving ≥2L therapy after documented EGFRex20ins; and (3) ≥2L postplatinum trial-aligned, or ≥2L patients previously treated with platinum chemotherapy whose baseline characteristics aligned with key eligibility criteria (initiating new treatment after documented EGFRex20ins and ≥1

SUBMITTER: Ou SI 

PROVIDER: S-EPMC10514080 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature