The impact of EV71 vaccination program on hand, foot and mouth disease in Zhejiang Province, China: A negative control study.

ABSTRACT:

Objective

To estimate the potential causal impact of Enterovirus A71 (EV71) vaccination program on the reduction of EV71-infected hand, foot, and mouth disease (HFMD) in Zhejiang Province.

Methods

We utilized the longitudinal surveillance dataset of HFMD and EV71 vaccination in Zhejiang Province during 2010-2019. We estimated vaccine efficacy using a Bayesian structured time series (BSTS) model, and employed a negative control outcome (NCO) model to detect unmeasured confounding and reveal potential causal association.

Results

We estimated that 20,132 EV71 cases (95% CI: 16,733, 23,532) were prevented by vaccination program during 2017-2019, corresponding to a reduction of 29% (95% CI: 24%, 34%). The effectiveness of vaccination increased annually, with reductions of

SUBMITTER: Zheng D 

PROVIDER: S-EPMC10514095 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature