IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE.

ABSTRACT: Interleukin-17A plays a crucial role in multiple sclerosis and other autoimmune diseases. Although the link between IL-17 and disease activity has been clearly demonstrated, the precise function of this cytokine remains elusive. Here, we investigated the function of astrocyte-targeted IL-17A production in GF/IL-17 transgenic mice during EAE. In particular, IL-17A is important during disease induction. In mice with transgenic IL-17A production, disease occurs earlier and peak disease is more severe, whereas remission is unimpaired. IL-17A synthesis is associated with increased infiltration of granulocytes into the CNS and microglial activation. Moreover, IL-17A synthesis allows induction of MOG-EAE without the additional administration of the co-adjuvant pertussis toxin. Examination of doub

SUBMITTER: Zimmermann J 

PROVIDER: S-EPMC10514131 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature