Radioprotective potential of probiotics against gastrointestinal and neuronal toxicity: a preclinical study.

ABSTRACT:

Purpose

Radiotherapy is a critical component of cancer treatment, along with surgery and chemotherapy. Approximately, 90% of cancer patients undergoing pelvic radiotherapy show gastrointestinal (GI) toxicity, including bloody diarrhea, and gastritis, most of which are associated with gut dysbiosis. In addition to the direct effect of radiation on the brain, pelvic irradiation can alter the gut microbiome, leading to inflammation and breakdown of the gut-blood barrier. This allows toxins and bacteria to enter the bloodstream and reach the brain. Probiotics have been proven to prevent GI toxicity by producing short-chain fatty acids and exopolysaccharides beneficial for protecting mucosal integrity and oxidative stress reduction in the intestine and also shown to be beneficial in bra

SUBMITTER: Venkidesh BS 

PROVIDER: S-EPMC10514165 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature