Characterization of signal and transit peptides based on motif composition and taxon-specific patterns.

ABSTRACT: Targeting peptides or presequences are N-terminal extensions of proteins that encode information about their cellular localization. They include signal peptides (SP), which target proteins to the endoplasmic reticulum, and transit peptides (TP) directing proteins to the organelles of endosymbiotic origin: chloroplasts and mitochondria. TPs were hypothesized to have evolved from antimicrobial peptides (AMPs), which are responsible for the host defence against microorganisms, including bacteria, fungi and viruses. In this study, we performed comprehensive bioinformatic analyses of amino acid motifs of targeting peptides and AMPs using a curated set of experimentally verified proteins. We identified motifs frequently occurring in each type of presequence showing specific patterns associated w

SUBMITTER: Sidorczuk K 

PROVIDER: S-EPMC10514287 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature