Expression of the schizophrenia associated gene FEZ1 in the early developing fetal human forebrain.

ABSTRACT:

Introduction

The protein fasciculation and elongation zeta-1 (FEZ1) is involved in axon outgrowth but potentially interacts with various proteins with roles ranging from intracellular transport to transcription regulation. Gene association and other studies have identified FEZ1 as being directly, or indirectly, implicated in schizophrenia susceptibility. To explore potential roles in normal early human forebrain neurodevelopment, we mapped FEZ1 expression by region and cell type.

Methods

All tissues were provided with maternal consent and ethical approval by the Human Developmental Biology Resource. RNAseq data were obtained from previously published sources. Thin paraffin sections from 8 to 21 post-conceptional weeks (PCW) samples were used for RNAScope in

SUBMITTER: Alhesain M 

PROVIDER: S-EPMC10514365 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature