Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids.

ABSTRACT:

Introduction

The lung is a difficult organ to regenerate, and the development of functional lungs has still not been achieved. In this study, we investigated lung regeneration using a rat fetal lung tissue-implanted model. This study aimed to evaluate the functioning of the implanted fetal lung tissue and investigate the graft differentiation and maturation mechanism, focusing on alveolar stem cells.

Methods

Fetal lung tissue fragments were obtained from Lewis rats on day 17 and implanted into adult lungs. Animals were divided into the following three groups: group 1, injection into the adult left lung parenchyma; group 2, injection with post-caval lobectomy; and group 3, injection with post-caval lobectomy and corticosteroid administration. Computed tomography was performed

SUBMITTER: Matsumoto D 

PROVIDER: S-EPMC10514393 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature