Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study.

ABSTRACT:

Background

Metformin shows beneficial effects on cardiometabolic health in diabetic individuals. However, the beneficial effects in the general population, especially in non-diabetic individuals are unclear. We aim to estimate the effects of perturbation of seven metformin targets on cardiometabolic health using Mendelian randomization (MR).

Methods

Genetic variants close to metformin-targeted genes associated with expression of the corresponding genes and glycated haemoglobin (HbA_1c) level were used to proxy therapeutic effects of seven metformin-related drug targets. Eight cardiometabolic phenotypes under metformin trials were selected as outcomes (average N = 466,947). MR estimates representing the weighted average effects of the seven effects of metformin targ

SUBMITTER: Zheng J 

PROVIDER: S-EPMC10514430 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature