The Cxcr2⁺ subset of the S100a8⁺ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology.

ABSTRACT:

Introduction

Gastric myeloid-derived suppressor cells (MDSCs) are a prominent population that expands during gastric pre-neoplastic and neoplastic development in humans and mice. However, the heterogeneity of this population has circumvented the ability to study these cells or understand their functions. Aside from Schlafen-4⁺ (Slfn-4⁺) MDSCs in mouse studies, which constitute a subset of this population, limitations exist in characterizing the heterogeneity of the gastric CD11b⁺Ly6G⁺ population and targeting its different subsets. Here we identify S100a8 as a pan-specific marker for this population and utilize it to study the role of the S100a8⁺Cxcr2⁺ subset.

Methods

We profiled gastric CD11b⁺Ly6G<

SUBMITTER: Kao KD 

PROVIDER: S-EPMC10514515 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature