Extracellular microRNAs in Relation to Weight Loss-A Systematic Review and Meta-Analysis.

ABSTRACT: Obesity is an important risk factor for cardiovascular disease and type 2 diabetes mellitus. Even a modest weight loss of 5-15% improves metabolic health, but circulating markers to indicate weight loss efficiency are lacking. MicroRNAs, small non-coding post-transcriptional regulators of gene expression, are secreted from tissues into the circulation and may be potential biomarkers for metabolic health. However, it is not known which specific microRNA species are reproducibly changed in levels by weight loss. In this study, we performed a systematic review and meta-analysis to investigate the microRNAs associated with weight loss by comparing baseline to follow-up levels following intervention-driven weight loss. This systematic review was performed according to the PRISMA guidelines with

SUBMITTER: Veie CHB 

PROVIDER: S-EPMC10514795 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature