Identification of the expression patterns and potential prognostic role of m6A-RNA methylation regulators in Wilms Tumor.

ABSTRACT:

Background

To explore the potential role of m6A methylation modification in Wilms Tumor (WT) by m6A-RNA Methylation (m6A) regulators.

Methodology

The association of m6A modification patterns with immune and prognostic characteristics of tumors was systematically evaluated using 19 m6A regulators extracted from Wilms Tumor's samples in public databases. A comprehensive model of "m6Ascore" was constructed using principal component analysis, and its prognostic value was evaluated.

Results

Almost all m6A regulators were differentially expressed between WT and normal tissues. Unsupervised clustering identified three distinct m6A clusters that differed in both immune cell infiltration and biological pathways. The m6Ascore was constructed to quantify m6A modifications in ind

SUBMITTER: Jia C 

PROVIDER: S-EPMC10514975 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature