Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but subcutaneous fat (SC) stromal cells derived exosomes (MSCs^SC-Exos), especially engineering MSCs^SC-Exos for drug delivery have been rarely reported in OA therapy. This objective of this study was to clarify the underlying mechanism of MSCs^SC-Exos on cartilage repair and therapy of engineering MSCs^SC-Exos for drug delivery in OA. MSCs^SC-Exos could ameliorate the pathological severity degree of cartilage via miR-199a-3p, a novel molecular highly enriched in MSCs^SC-Exos, which could mediate the mTOR-autophagy pathway in OA rat model. Intra-articular injectio

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10515007 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature