Identification of key lipid metabolism-related genes in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) represents profound degenerative conditions of the brain that cause significant deterioration in memory and cognitive function. Despite extensive research on the significant contribution of lipid metabolism to AD progression, the precise mechanisms remain incompletely understood. Hence, this study aimed to identify key differentially expressed lipid metabolism-related genes (DELMRGs) in AD progression.

Methods

Comprehensive analyses were performed to determine key DELMRGs in AD compared to controls in GSE122063 dataset from Gene Expression Omnibus. Additionally, the ssGSEA algorithm was utilized for estimating immune cell levels. Subsequently, correlations between key DELMRGs and each immune cell were calculated specifically in AD samples.

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC10515010 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature