Metagenomic sequencing reveals altered gut microbial compositions and gene functions in patients with non-segmental vitiligo.

ABSTRACT:

Background

Vitiligo has been correlated with an abnormal gut microbiota. We aimed to systematically identify characteristics of the gut microbial compositions, genetic functions, and potential metabolic features in patients with non-segmental vitiligo.

Methods

Twenty-five patients with non-segmental vitiligo and 25 matched healthy controls (HCs) were enrolled. Metagenomic sequencing and bioinformatic analysis were performed to determine the gut microbiota profiles. Differences in gut microbiota diversity and composition between patients with vitiligo and HCs were analyzed. Gene functions and gut metabolic modules were predicted with the Kyoto Encyclopedia of Gene and Genomes (KEGG) and MetaCyc databases.

Results

Compared with HCs, alpha diversity of intestinal microbi

SUBMITTER: Luan M 

PROVIDER: S-EPMC10515041 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature