An inference model gives insights into innate immune adaptation and repertoire diversity.

ABSTRACT: The innate immune system is the body's first line of defense against infection. Natural killer (NK) cells, a vital part of the innate immune system, help to control infection and eliminate cancer. Studies have identified a vast array of receptors that NK cells use to discriminate between healthy and unhealthy cells. However, at present, it is difficult to explain how NK cells will respond to novel stimuli in different environments. In addition, the expression of different receptors on individual NK cells is highly stochastic, but the reason for these variegated expression patterns is unclear. Here, we studied the recognition of unhealthy target cells as an inference problem, where NK cells must distinguish between healthy targets with normal variability in ligand expression and ones that a

SUBMITTER: Qin Y 

PROVIDER: S-EPMC10515141 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature