Risk factor analysis for adverse prognosis of the fetal ventricular septal defect (VSD).

ABSTRACT:

Background

Ventricular septal defect (VSD) is the most common subtype of congenital heart disease. In the present study, we aimed to determine whether chromosome aberration was associated with the occurrence of VSD and evaluate the association of VSD size, location and chromosome aberration with adverse outcomes in the Chinese fetuses.

Methods

Fetuses with VSD and comprehensive follow-up data were included and evaluated retrospectively. Medical records were used to collect epidemiological data and foetal outcomes. For VSD fetuses, conventional karyotype and microarray analysis were conducted. After adjusting confounding factors by using multivariable logistic regression analyses, the association between chromosome variations and VSD occurrence was explored. The association b

SUBMITTER: Shan W 

PROVIDER: S-EPMC10515257 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature