A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus.

ABSTRACT:

Background

Cells orchestrate histone biogenesis with strict temporal and quantitative control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered at a single locus. Regulatory factors concentrate in a nuclear body known as the histone locus body (HLB), which forms around the locus. Historically, HLB factors are largely discovered by chance, and few are known to interact directly with DNA. It is therefore unclear how the histone genes are specifically targeted for unique and coordinated regulation.

Results

To expand the list of known HLB factors, we performed a candidate-based screen by mapping 30 publicly available ChIP datasets of 27 unique factors to the Drosophila histone gene ar

SUBMITTER: Hodkinson LJ 

PROVIDER: S-EPMC10515271 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature