Plasmodium falciparum infection of human erythroblasts induces transcriptional changes associated with dyserythropoiesis.

ABSTRACT: During development down the erythroid lineage, hematopoietic stem cells undergo dramatic changes to cellular morphology and function in response to a complex and tightly regulated program of gene expression. In malaria infection, Plasmodium spp parasites accumulate in the bone marrow parenchyma, and emerging evidence suggests erythroblastic islands are a protective site for parasite development into gametocytes. Although it has been observed that Plasmodium falciparum infection in late-stage erythroblasts can delay terminal erythroid differentiation and enucleation, the mechanism(s) underlying this phenomenon are unknown. Here, we apply RNA sequencing after fluorescence-activated cell sorting of infected erythroblasts to identify transcriptional responses to direct and indirect interaction

SUBMITTER: Feldman TP 

PROVIDER: S-EPMC10515311 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature