Early Deficits in Dentate Circuit and Behavioral Pattern Separation after Concussive Brain Injury.

ABSTRACT: Traumatic brain injury leads to cellular and circuit changes in the dentate gyrus, a gateway to hippocampal information processing. Intrinsic granule cell firing properties and strong feedback inhibition in the dentate are proposed as critical to its ability to generate unique representation of similar inputs by a process known as pattern separation. Here we evaluate the impact of brain injury on cellular decorrelation of temporally patterned inputs in slices and behavioral discrimination of spatial locations in vivo one week after concussive lateral fluid percussion injury (FPI) in mice. Despite posttraumatic increases in perforant path evoked excitatory drive to granule cells and enhanced ΔFosB labeling, indicating sustained increase in excitability, the reliability of granule cel

SUBMITTER: Corrubia L 

PROVIDER: S-EPMC10515770 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature