Brain-wide functional connectivity artifactually inflates throughout fMRI scans: a problem and solution.

ABSTRACT: The fMRI blood oxygen level-dependent (BOLD) signal is a mainstay of neuroimaging assessment of neuronal activity and functional connectivity in vivo. Thus, a chief priority is maximizing this signal's reliability and validity. To this end, the fMRI community has invested considerable effort into optimizing both experimental designs and physiological denoising procedures to improve the accuracy, across-scan reproducibility, and subject discriminability of BOLD-derived metrics like functional connectivity. Despite these advances, we discover that a substantial and ubiquitous defect remains in fMRI datasets: functional connectivity throughout the brain artifactually inflates during the course of fMRI scans - by an average of more than 70% in 15 minutes of scan time - at spatially hete

SUBMITTER: Korponay C 

PROVIDER: S-EPMC10515781 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature