Examining DNA Breathing with pyDNA-EPBD.

ABSTRACT:

Motivation

The two strands of the DNA double helix locally and spontaneously separate and recombine in living cells due to the inherent thermal DNA motion.This dynamics results in transient openings in the double helix and is referred to as "DNA breathing" or "DNA bubbles." The propensity to form local transient openings is important in a wide range of biological processes, such as transcription, replication, and transcription factors binding. However, the modeling and computer simulation of these phenomena, have remained a challenge due to the complex interplay of numerous factors, such as, temperature, salt content, DNA sequence, hydrogen bonding, base stacking, and others.

Results

We present pyDNA-EPBD, a parallel software implementation of the Extended Peyrard-Bishop- Da

SUBMITTER: Kabir A 

PROVIDER: S-EPMC10515784 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature