Modularity of biological systems: a link between structure and function.

ABSTRACT: This paper addresses two topics in systems biology, the hypothesis that biological systems are modular and the problem of relating structure and function of biological systems. The focus here is on gene regulatory networks, represented by Boolean network models, a commonly used tool. Most of the research on gene regulatory network modularity has focused on network structure, typically represented through either directed or undirected graphs. But since gene regulation is a highly dynamic process as it determines the function of cells over time, it is natural to consider functional modularity as well. One of the main results is that the structural decomposition of a network into modules induces an analogous decomposition of the dynamic structure, exhibiting a strong relationship between netw

SUBMITTER: Kadelka C 

PROVIDER: S-EPMC10515856 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature