Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence.

ABSTRACT:

Rationale

Preclinical studies report attenuated ethanol-induced conditioned taste aversion (CTA) following chronic ethanol exposure, suggesting that tolerance develops to the aversive properties of ethanol. However, these studies are confounded by pre-exposure to the unconditioned stimulus (US; ethanol), which is well known to hinder conditioning.

Objectives

This study was designed to determine whether chronic ethanol exposure produces tolerance to the aversive properties of ethanol in the absence of a US pre-exposure confound.

Methods

CTA was performed in adult male and female Long-Evans rats by pairing 0.1% ingested saccharin with an intraperitoneal injection of ethanol (1.5 or 2.0 g/kg) or saline. Rats were then rendered ethanol dependent using chronic intermittent

SUBMITTER: Ramirez LA 

PROVIDER: S-EPMC10515951 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature