Cerebellar circuits for disinhibition and synchronous inhibition.

ABSTRACT: The cerebellar cortex contributes to diverse behaviors by transforming mossy fiber inputs into predictions in the form of Purkinje cell (PC) outputs, and then refining those predictions¹. Molecular layer interneurons (MLIs) account for approximately 80% of the inhibitory interneurons in the cerebellar cortex², and are vital to cerebellar processing^1,3. MLIs are thought to primarily inhibit PCs and suppress the plasticity of excitatory synapses onto PCs. MLIs also inhibit, and are electrically coupled to, other MLIs^4-7, but the functional significance of these connections is not known^1,3. Behavioral studies suggest that cerebellar-dependent learning is gated by disinhibition of PCs, but the source of such disinhibition has not been iden

SUBMITTER: Lackey EP 

PROVIDER: S-EPMC10516046 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature