Determinants of <i>de novo</i> B cell responses to drifted epitopes in post-vaccination SARS-CoV-2 infections.

ABSTRACT: Vaccine-induced immunity may impact subsequent de novo responses to drifted epitopes in SARS-CoV-2 variants, but this has been difficult to quantify due to the challenges in recruiting unvaccinated control groups whose first exposure to SARS-CoV-2 is a primary infection. Through local, statewide, and national SARS-CoV-2 testing programs, we were able to recruit cohorts of individuals who had recovered from either primary or post-vaccination infections by either the Delta or Omicron BA.1 variants. Regardless of variant, we observed greater Spike-specific and neutralizing antibody responses in post-vaccination infections than in those who were infected without prior vaccination. Through analysis of variant-specific memory B cells as markers of de novo responses, we observed tha

SUBMITTER: Quirk GE 

PROVIDER: S-EPMC10516057 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature