Preferences of people living with HIV for features of tuberculosis preventive treatment regimens - a discrete choice experiment.

ABSTRACT:

Background

Tuberculosis (TB) preventive treatment (TPT) is recommended for people living with HIV (PLHIV) in high TB burden settings. While 6 months of daily isoniazid remains widely used, shorter regimens are now available. However, little is known about preferences of PLHIV for key features of TPT regimens.

Methods

We conducted a discrete choice experiment among adult PLHIV engaged in care at an urban HIV clinic in Kampala, Uganda. In nine random choice tasks, participants chose between two hypothetical TPT regimens with different features (pills per dose, frequency, duration, need for adjusted antiretroviral therapy [ART] dosage and side effects). We analyzed preferences using hierarchical Bayesian estimation, latent class analysis, and willingness-to-trade simulations.

SUBMITTER: Aschmann HE 

PROVIDER: S-EPMC10516058 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature