Development and Standardization of a Classification System for Osteoradionecrosis: Implementation of a Risk-Based Model.

ABSTRACT:

Purpose

Osteoradionecrosis of the jaw (ORN) can manifest in varying severity. The aim of this study is to identify ORN risk factors and develop a novel classification to depict the severity of ORN.

Methods

Consecutive head-and-neck cancer (HNC) patients treated with curative-intent IMRT (≥ 45Gy) in 2011-2018 were included. Occurrence of ORN was identified from in-house prospective dental and clinical databases and charts. Multivariable logistic regression model was used to identify risk factors and stratify patients into high-risk and low-risk groups. A novel ORN classification system was developed to depict ORN severity by modifying existing systems and incorporating expert opinion. The performance of the novel system was compared to fifteen existing systems for their abili

SUBMITTER: Watson EE 

PROVIDER: S-EPMC10516072 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature