Pleiotropic Genetic Effects between Multiple Sclerosis and Musculoskeletal Traits.

ABSTRACT:

Background

Musculoskeletal disorders were commonly reported in patients with multiple sclerosis. However, the underlying etiology linking Multiple Sclerosis (MS) and musculoskeletal disorders is not well studied. With large-scale Genome-Wide Association Studies (GWAS) publicly available, we conducted genetic correlation analysis to identify shared pleiotropic genetic effects between MS and musculoskeletal traits. We also conducted Mendelian Randomization (MR) to estimate the causal relation between MS and increased risks of musculoskeletal disorders.

Methods

Linkage Disequilibrium Score Regression (LDSR) analysis was performed to estimate heritability and genetic correlation. Univariable, multivariable, and bidirectional MR analyses were conducted to estimate the causal rela

SUBMITTER: Jeong S 

PROVIDER: S-EPMC10516081 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature