Regulatory mechanisms controlling store-operated calcium entry.

ABSTRACT: Calcium influx through plasma membrane ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP₃), which binds to IP₃ receptors (IP₃R) in the endoplasmic reticulum (ER) to release calcium pools from the ER lumen. This leads to the depletion of ER calcium pools, which has been termed store depletion. Store depletion leads to the dissociation of calcium ions from the EF-hand motif of the ER calcium sensor Stromal Interaction Molecule 1 (STIM1). This leads to a conformational change in STIM1, which helps it to interact with the plasma membrane (PM) at ER:PM junctions. At these ER:PM junctions, STIM1 binds to and activates a calcium channel known as Orai1 to form calcium-rele

SUBMITTER: Kodakandla G 

PROVIDER: S-EPMC10516112 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature